Potential biomarkers of ductal carcinoma in situ progression
نویسندگان
چکیده
منابع مشابه
Biomarkers predicting recurrence and progression of ductal carcinoma in situ treated by lumpectomy alone.
An interesting article by Kerlikowske et al. (1) in this issue of the Journal describes how certain biomarkers in ductal carcinoma in situ (DCIS) treated with lumpectomy alone may improve our ability to predict the risk of disease recurrence and progression to invasive breast cancer (IBC). Once DCIS is detected, this therapeutic setting reflects the natural history of any residual disease, and ...
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Ductal carcinoma in situ (DCIS) now represents up to 20% of breast cancer cases, yet its behaviour is still poorly understood. Morphological classifications go some way to predicting prognosis, but more sophisticated approaches are required to better tailor therapy to the individual. A number of biological molecules have been identified that appear to relate to prognosis and, in model systems, ...
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Ductal carcinoma in situ (DCIS) is an often-diagnosed breast disease and a known, non-obligate, precursor to invasive breast carcinoma. In this review, we explore the clinical and pathological features of DCIS, fundamental elements of DCIS biology including gene expression and genetic events, the relationship of DCIS with recurrence and invasive breast cancer, and the interaction of DCIS with t...
متن کاملMyoepithelial cell differentiation markers in ductal carcinoma in situ progression.
We describe a preclinical model that investigates progression of early-stage ductal carcinoma in situ (DCIS) and report that compromised myoepithelial cell differentiation occurs before transition to invasive disease. Human breast cancer MCF10DCIS.com cells were delivered into the mouse mammary teat by intraductal injection in the absence of surgical manipulations and accompanying wound-healing...
متن کاملSOX11 promotes invasive growth and ductal carcinoma in situ progression
Here, we show that SOX11, an embryonic mammary marker that is normally silent in postnatal breast cells, is expressed in many oestrogen receptor-negative preinvasive ductal carcinoma in situ (DCIS) lesions. Mature mammary epithelial cells engineered to express SOX11 showed alterations in progenitor cell populations, including an expanded basal-like population with increased aldehyde dehydrogena...
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ژورنال
عنوان ژورنال: BMC Cancer
سال: 2020
ISSN: 1471-2407
DOI: 10.1186/s12885-020-6608-y